This short blog posts shares new considerations of thought around the mechanism of placental transfusion and onset of breathing and introduces some of the very latest research.
Is spontaneous breathing the driver for placental transfusion?
Placental transfusion is a widely accepted benefit of delaying cord clamping, as described in many scientific publications. Waiting to clamp the cord results in a net shift of blood volume from the placenta to the neonate and with that, improves iron stores during infancy and supports health and development for the growing child. Nevertheless, the exact underlying physiological mechanisms of placental transfusion still remain unclear, making placental transfusion a topic of many scientific debate.
What about the influence of gravity or uterine contraction?
The effect of gravity may be less than many people assume. In the human study by Nestor Vain (Vain at al 2014), he found that the position of the newborn baby before cord clamping does not affect the volume of placental transfusion. Experimental studies with lambs by Stuart Hooper show that the umbilical venous flow is closely related to the umbilical arterial flow, suggesting that what goes into the placenta largely determines what goes out, regardless of the position of the baby in relation to the placenta (Hooper et al 2017).
How about spontaneous breathing?
In a study by Isabelle Boere, published in 2015, it was observed that venous and arterial umbilical flow occur for much longer than previously described and is unrelated to the cessation of pulsations in the umbilical cord.
In many babies, the umbilical cord flow does not stop within 3 min and continues after the cord is white and stops pulsating.
It was also observed that there is a large influence of the infants’ first spontaneous breaths on the venous flow patterns, suggesting that spontaneous breathing could play an important role in placental transfusion (Boere et al 2015).
Last month, on September 22nd, Dr. Emma Brouwer successfully defended her PhD thesis; “Physiological measurements of the effect of cord clamping strategies”. Her work includes interesting new findings and suggestions on the mechanism that may be responsible for placental transfusion.
One of these findings is the effect of spontaneous brea